Three-week run hopes to “play a positive role in bringing the artistic pulse of the community back to life.”
From a grand piano, Gaga played “Million Reasons”, “Edge of Glory”, and “You And I”.
Gloria Estefan, Fat Joe, John Leguizamo, and more also appear on the Spanish-language track.
She’s also raising money to help rebuild her home country of Puerto Rico in the wake of Hurricane Maria.
Proceeds from the event will go to natural disaster relief efforts.
“This today is a celebration of survival. Y’all are my family. Houston is my home.”